Elucidating the role of 8q24 in colorectal cancer
This is particularly important when the recommended agent is a new and/or infrequently employed drug.Abstract: Genome-wide association studies (GWASs) and a number of case–control studies have suggested that several single nucleotide polymorphisms (SNPs), rs7837328, rs7014346, rs6983267, rs10505477 on CASC8 gene and rs4939827, rs4464148, rs12953717 on gene are significantly correlated with the susceptibility to colorectal cancer (CRC).Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication.However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions.Also subgroup analysis was performed by ethnicity (Caucasian, Asian, and African) and all of the analyses were implemented in R 3.2.1 software.Pooled data from the meta-analysis revealed that the A allele of rs7837328, the A allele of rs7014346, the G allele of rs6983267, the A allele of rs10505477, the T allele of rs4939827, the T of rs4464148, and the T of rs12953717 were significantly associated with an increased risk of CRC under the allelic model.Little, however, is known about the involvement of c-myc in the progression of colorectal cancer.
A total of 34 articles including 90 studies (168,471 cases and 163,223 controls) that evaluated the relationship between the genes and the risk of CRC under the allelic model were reviewed.
Our study suggested that for From the Department of General Surgery, Huaihe Hospital of Henan University, Kaifeng, Henan Province, China (KY, LH, JM, JH); and Department of Digestive Medicine, Huaihe Hospital of Henan University, Kaifeng, Henan Province, China (LW).
Correspondence: Junhong Hu, Department of General Surgery, Huaihe Hospital of Henan University, #8 Baobei Road, Gulou District, Kaifeng 475000, Henan Province, China (e-mail: ).
Phospholipid remodeling and eicosanoid synthesis are central to lipid-based inflammatory reactions.
Studies have revealed that membrane phospholipid remodeling by fatty acids through deacylation/reacylation reactions increases the risk of colorectal cancers (CRC) by allowing the cells to produce excess inflammatory eicosanoids, such as prostaglandins, thromboxanes and leukotrienes.